rs2167270

A SNP in the LEP gene on chromosome 7. Its most notable genotype is A;A: 0.79x reduced risk for colon cancer

Gene
LEP
Location
Chr 7128,241,296 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated0.79x reduced risk for colon cancerTypical · 0.012% of people
  2. A;GNot ratednormalTypical · 0.045% of people
  3. G;GGoodnormalTypical · 0.043% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 12% A;G 45% G;G 43%
  • European ancestry (Utah)A;A 14% A;G 43% G;G 43%
  • Han Chinese (Beijing)A;A 3% A;G 29% G;G 68%
  • Japanese (Tokyo)A;A 2% A;G 33% G;G 66%
  • Yoruba (Nigeria)A;A 24% A;G 47% G;G 29%
  • African ancestry (Southwest US)A;A 16% A;G 54% G;G 30%
  • Chinese (Denver)A;A 8% A;G 39% G;G 52%
  • Gujarati IndianA;A 7% A;G 48% G;G 46%
  • Luhya (Kenya)A;A 21% A;G 56% G;G 24%
  • Mexican ancestry (Los Angeles)A;A 22% A;G 55% G;G 22%
  • Maasai (Kenya)A;A 7% A;G 44% G;G 50%
  • TuscanA;A 9% A;G 47% G;G 44%

Conditions, medicines and genes

Other LEP SNPs

All LEP SNPs

Notes

From SNPedia

Show notes, about 130 words

rs2167270 is a SNP in the leptin LEP gene. In a study of ~1,500 colon cancer patients, the rs2167270(A;A) genotype was underrepresented, leading to an odds ratio of 0.79 (CI: 0.64-0.98). Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Adipokine genes and prostate cancer risk. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Association of maternally inherited GNAS alleles with African-American male birth weight. Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis.

Source and license

Adapted from rs2167270 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.