rs110419

A SNP in the LMO1 gene on chromosome 11. Its most notable genotype is A;A: 1.7x increased risk for neuroblastoma

Gene
LMO1
Location
Chr 118,231,306 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.7x increased risk for neuroblastomaWorth knowing · 2.038% of people
  2. A;GBad1.3x increased risk for neuroblastomaMinor · 1.342% of people
  3. G;GNot ratedNo summary available.Typical · 0.020% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 38% A;G 42% G;G 20%
  • European ancestry (Utah)A;A 27% A;G 48% G;G 26%
  • Han Chinese (Beijing)A;A 31% A;G 50% G;G 20%
  • Japanese (Tokyo)A;A 41% A;G 49% G;G 11%
  • Yoruba (Nigeria)A;A 66% A;G 31% G;G 3%
  • African ancestry (Southwest US)A;A 61% A;G 33% G;G 5%
  • Chinese (Denver)A;A 32% A;G 46% G;G 22%
  • Gujarati IndianA;A 6% A;G 36% G;G 58%
  • Luhya (Kenya)A;A 75% A;G 23% G;G 3%
  • Mexican ancestry (Los Angeles)A;A 17% A;G 52% G;G 31%
  • Maasai (Kenya)A;A 51% A;G 39% G;G 10%
  • TuscanA;A 15% A;G 58% G;G 28%

Conditions, medicines and genes

Other LMO1 SNPs

All LMO1 SNPs

Notes

From SNPedia

Notes

rs110419 is a SNP in the LMO1 LIM domain only 1 (rhombotin 1) gene. A GWAS study of 2,000+ patients (and 6,000+ controls) concluded that the rs110419(A) allele is associated with increased risk for neuroblastoma, with an allelic odds ratio of 1.34 (CI: 1.25 - 1.44, combined p = 5.2 x 10e-16).

Source and license

Adapted from rs110419 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.