rs2168101
A SNP in the LMO1 gene on chromosome 11. Its most notable genotype is C;C: common in clinvar
- Gene
- LMO1
- Location
- Chr 118,233,861 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2168101 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 2 HapMap populations.
- AverageC;C 76%
- European ancestry (Utah)C;C 52%
- Yoruba (Nigeria)C;C 100%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism: SNP rs2168101 G>T is the most highly associated variant (combined p = 7.47 × 10e−29, odds ratio 0.65, CI: 0.60–0.70), and resides in a super-enhancer defined by extensive acetylation of histone H3 lysine 27 within the first intron of the LMO1 gene. The ancestral G allele that is associated with tumour formation resides in a conserved GATA transcription factor binding motif. The newly evolved protective TATA allele is associated with decreased total LMO1 expression (p = 0.028) in neuroblastoma primary tumours.
Source and license
Adapted from rs2168101 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.