rs11085825
A SNP in the GCDH gene on chromosome 19. Its most notable genotype is C;T: most likely benign polymorphism
- Gene
- GCDH
- Location
- Chr 1912,896,644 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableGoodmost likely benign polymorphism
- T;TGoodmost likely benign polymorphism
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 61% C;T 32% T;T 7%
- European ancestry (Utah)C;C 42% C;T 48% T;T 11%
- Han Chinese (Beijing)C;C 75% C;T 23% T;T 2%
- Japanese (Tokyo)C;C 71% C;T 27% T;T 2%
- Yoruba (Nigeria)C;C 76% C;T 24% T;T <1%
- African ancestry (Southwest US)C;C 70% C;T 23% T;T 7%
- Chinese (Denver)C;C 74% C;T 23% T;T 3%
- Gujarati IndianC;C 53% C;T 42% T;T 6%
- Luhya (Kenya)C;C 69% C;T 29% T;T 2%
- Mexican ancestry (Los Angeles)C;C 28% C;T 40% T;T 33%
- Maasai (Kenya)C;C 67% C;T 31% T;T 2%
- TuscanC;C 49% C;T 38% T;T 13%
Related
Other GCDH SNPs
- rs121434367T;Tglutaric acidemia type IVery important
- rs121434366C;TCarrier of a Glutaric aciduria type I mutationImportant
- rs121434368C;TCarrier of a Glutaric aciduria type I mutationImportant
- rs142967670A;CCarrier of a Glutaric aciduria type I mutationImportant
- rs199999619A;CCarrier of a Glutaric aciduria type I mutationImportant
- rs566417795A;GCarrier of a Glutaric aciduria type I mutationImportant
- rs752334462C;TCarrier of a Glutaric aciduria type I mutationImportant
- rs777201305A;GCarrier of a Glutaric aciduria type I mutationImportant
Notes
From SNPedia
Notes
aka c.852+223C>T ClinVar indicates "likely pathogenic" (for glutaric aciduria, type 1) according to a single submitter, but with a population frequency as high as 10% for the minor allele homozygote, this seems very unlikely to be correct and instead this variant is most likely not pathogenic.
Source and license
Adapted from rs11085825 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.