rs121434367
A SNP in the GCDH gene on chromosome 19. Its most notable genotype is T;T: glutaric acidemia type I
- Gene
- GCDH
- Location
- Chr 1912,899,486 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TBadCarrier of a glutaric acidemia type I mutation
- T;TMost notableBadglutaric acidemia type I
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other GCDH SNPs
- rs121434366C;TCarrier of a Glutaric aciduria type I mutationImportant
- rs121434368C;TCarrier of a Glutaric aciduria type I mutationImportant
- rs142967670A;CCarrier of a Glutaric aciduria type I mutationImportant
- rs199999619A;CCarrier of a Glutaric aciduria type I mutationImportant
- rs566417795A;GCarrier of a Glutaric aciduria type I mutationImportant
- rs752334462C;TCarrier of a Glutaric aciduria type I mutationImportant
- rs777201305A;GCarrier of a Glutaric aciduria type I mutationImportant
- rs786205861C;TCarrier of a Glutaric aciduria type I mutationImportant
Notes
From SNPedia
Notes
aka c.1262C>T (p.Ala421Val or A421V); may be referred to as the Amish GA1 mutation
C;T
Unaffected in absence of a second GCDH mutation
T;T
see text and links via main rs-page
Source and license
Adapted from rs121434367 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.