rs11090865

A SNP in the TRMU gene on chromosome 22. Its most notable genotype is T;T: Modifier variant; some impact in rare cases

Gene
TRMU
Location
Chr 2246,335,792 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.084% of people
  2. G;TBadCarrier of a deafness-related modifier variantWorth knowing · 2.314% of people
  3. T;TMost notableBadModifier variant; some impact in rare casesImportant · 3.02% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 84% G;T 14% T;T 2%
  • European ancestry (Utah)G;G 68% G;T 31% T;T 2%
  • Han Chinese (Beijing)G;G 100% G;T 0% T;T 0%
  • Japanese (Tokyo)G;G 100% G;T 0% T;T 0%
  • Yoruba (Nigeria)G;G 70% G;T 24% T;T 6%

Conditions, medicines and genes

Notes

From SNPedia

Notes

This SNP, also known as c.28G>T, p.Ala10Ser or A10S, represents a variant in the TRMU gene on chromosome 22. Individuals who are homozygous TRMU A10S (i.e. rs11090865(T;T)) *AND* who also carry the mtDNA A1555G mutation (rs267606617(G)) exhibit prelingual profound deafness.

G;T

See text of main rs-page

T;T

See text on main rs-page

Source and license

Adapted from rs11090865 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.