Deafness

148 SNPs linked to Deafness across 12 genes, 88 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 148
Notable: 88Magnitude 2 or higher
Well documented: 11
Genes: 12

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs28931594GJB2Very important
- T;TDeafness and keratitis; possible dominant or recessiveBad
- C;TDeafness and keratitis; possible dominant or recessiveBad
- C;Ccommon in clinvarGood
- A;CDeafness and keratitis; possible dominant or recessiveBad
- A;ADeafness and keratitis; possible dominant or recessiveBad
rs80338943GJB2Very important
- -;-deafness associatedBad
- -;Gcarrier of deafness-associated variantBad
- G;Gcommon in clinvarGood
rs267606617Very important
- A;Acommon in clinvarGood
- G;GHigh risk of developing hearing loss after taking aminoglycoside antibioticsBad
rs1052030MYO7AImportant
- A;TCarrier of a mutation for deafnessBad
- T;Tcommon in clinvarGood
rs11090865TRMUImportant
- G;Gcommon in clinvarGood
- G;TCarrier of a deafness-related modifier variantBad
- T;TModifier variant; some impact in rare casesBad
rs35887622GJB2Important
- A;Anormal hearingGood
- A;CCarrier of a recessive deafness mutationBad
- A;GVariant of unclear significance wrt deafnessBad
- G;GVariant of unclear significance wrt deafnessBad
rs80338947GJB2Important
- -;GAGCarrier of a recessive deafness mutationBad
- GAG;GAGcommon in clinvarGood
rs180275GNGT1Typical
- G;GNo summary available.Not rated
rs648298MYH14Typical
- T;TNo summary available.Not rated
- C;TNo summary available.Not rated
- C;CNo summary available.Not rated
rs726640Typical
- G;Gcommon in complete genomicsGood
rs71530923WFS1Typical
- C;Ccommon in clinvarGood
rs28929485GJB2Very important
- G;Gcommon in clinvarGood
- A;GDeafness and keratitis; possible dominant or recessiveBad
- C;CNo summary available.Not rated
- A;ADeafness and keratitis; possible dominant or recessiveBad
rs28931593GJB2Very important
- C;TPalmoplantar keratoderma with deafnessBad
- G;GNo summary available.Not rated
- C;Ccommon in clinvarGood
rs72561723GJB2Very important
- T;TDeafness and keratitis; possible dominant or recessiveBad
- C;TDeafness and keratitis; possible dominant or recessiveBad
- C;Ccommon in clinvarGood
rs74315437LOC105369301Very important
- T;TDeafness; early-onset (prelingual)Bad
- A;TCarrier of a deafness mutationBad
- A;Acommon in clinvarGood
rs74315438LOC105369301Very important
- T;TDeafness; early-onset (prelingual)Bad
- C;TCarrier of a deafness mutationBad
- C;Ccommon in clinvarGood
rs80338939GJB2Very important
- -;-deafness associatedBad
- -;Ccarrier of most common deafness-associated variant in CaucasiansBad
- C;Ccommon in clinvarGood
rs104894404GJB2Very important
- C;TNonsyndromic hearing loss and deafnessBad
- C;GPalmoplantar keratoderma with deafnessBad
- C;Ccommon in clinvarGood
rs104894408GJB2Very important
- G;GDeafness and keratitis; possible dominant or recessiveBad
- C;GDeafness and keratitis; possible dominant or recessiveBad
- C;Ccommon in clinvarGood
rs104894410GJB2Very important
- C;Tknuckle pads, leukonychia, and deafnessBad
- C;Ccommon in clinvarGood
rs104894412GJB2Very important
- G;Tknuckle pads, leukonychia, and deafnessBad
- G;Gcommon in clinvarGood
rs143797113CLDN14Very important
- A;ADeafness; early-onset (prelingual)Bad
- A;GCarrier of a deafness mutationBad
- G;Gcommon/normalGood
rs368027306CLDN14Very important
- C;Ccommon in clinvarGood
- C;TCarrier of a deafness mutationBad
- T;TDeafness; early-onset (prelingual)Bad
rs371100799CLDN14Very important
- C;Ccommon in clinvarGood
- C;TCarrier of a deafness mutationBad
- T;TDeafness; early-onset (prelingual)Bad
rs786200885CLDN14Very important
- -;-Deafness; early-onset (prelingual)Bad
- -;ACarrier of a deafness mutationBad
- A;Acommon in clinvarGood
rs786204841CLDN14Very important
- T;TDeafness; early-onset (prelingual)Bad
- C;TCarrier of a deafness mutationBad
- C;Ccommon in clinvarGood
rs61750427PEX1Very important
- G;GDeafness with enamel hypoplasia nail defectsBad
- A;GCarrier of a pathogenic mutation for a form of deafnessBad
- A;Acommon/normalGood
rs111033212SLC26A4Very important
- C;CPendred Syndrome (deafness)Bad
- C;TCarrier of a Pendred syndrome (deafness) mutationBad
- T;Tcommon in clinvarGood
rs28931595GJB2Very important
- C;TDeafness mutation (dominant)Bad
- C;Ccommon in clinvarGood
rs80338950GJB2Very important
- C;GDeafness mutation (dominant)Bad
- C;Ccommon in clinvarGood
rs104894401GJB2Very important
- C;TDeafness mutation (dominant)Bad
- C;Ccommon in clinvarGood
rs104894402GJB2Very important
- G;Gcommon in clinvarGood
- A;GDeafness mutation (dominant)Bad
rs104894406GJB2Very important
- C;Ccommon in clinvarGood
- A;CDeafness mutation (dominant)Bad
rs104894407GJB2Very important
- C;TCarrier of a recessive deafness mutationBad
- C;GDeafness mutation (dominant)Bad
- C;Ccommon in clinvarGood
rs104894413GJB2Very important
- C;TCarrier of a recessive deafness mutationBad
- C;GDeafness mutation (dominant)Bad
- C;Ccommon in clinvarGood
rs1801002GJB2Important
- C;Ccommon in clinvarGood
- A;CCarrier of a recessive deafness mutationBad
- GT;GTcommon in clinvarGood
- I;INo summary available.Good
rs28931592GJB2Important
- T;Tcommon in clinvarGood
- A;TCarrier of a recessive deafness mutationBad
- A;ANo summary available.Not rated
rs28937591OTOFImportant
- G;Gcommon in clinvarGood
- C;Cdeafness expectedNot rated
rs61729287PTPRQImportant
- C;Ccommon/normalGood
- C;TCarrier for a recessive mutation for deafnessBad
rs72474224GJB2Important
- A;CCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
- C;TCarrier of a recessive deafness mutationBad
rs80338940GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs80338941GJB2Important
- C;GCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs80338944GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs80338945GJB2Important
- A;GCarrier of a recessive deafness mutationBad
- A;Acommon in clinvarGood
rs80338946GJB2Important
- A;CCarrier of a recessive deafness mutationBad
- A;Acommon in clinvarGood
rs80338948GJB2Important
- G;Gcommon in clinvarGood
- A;GCarrier of a recessive deafness mutationBad
rs80338949GJB2Important
- T;Tcommon in clinvarGood
- C;TCarrier of a recessive deafness mutationBad
rs104894395GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs104894396GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs104894397GJB2Important
- A;GCarrier of a recessive deafness mutationBad
- A;Acommon in clinvarGood
rs104894398GJB2Important
- C;Ccommon in clinvarGood
- A;CCarrier of a recessive deafness mutationBad
rs104894409GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;GCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
- A;CCarrier of a recessive deafness mutationBad
rs111033190GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs111033194GJB2Important
- T;Tcommon/normalGood
- G;TCarrier of a recessive deafness mutationBad
rs111033204GJB2Important
- -;ATCarrier of a recessive deafness mutationBad
- AT;ATcommon in clinvarGood
rs111033217GJB2Important
- T;Tcommon in clinvarGood
- G;TCarrier of a recessive deafness mutationBad
rs111033253GJB2Important
- -;AAGTTCATCAAGGGCarrier of a recessive deafness mutationBad
- AAGTTCATCAAGGG;AAGTTCATCAAGGGcommon in clinvarGood
rs111033293GJB2Important
- T;Tcommon in clinvarGood
- C;TCarrier of a recessive deafness mutationBad
rs111033294GJB2Important
- T;Tcommon in clinvarGood
- C;TCarrier of a recessive deafness mutationBad
rs111033295GJB2Important
- T;Tcommon in clinvarGood
- A;TCarrier of a recessive deafness mutationBad
rs111033296GJB2Important
- G;Gcommon in clinvarGood
- C;GCarrier of a recessive deafness mutationBad
rs111033297GJB2Important
- G;Gcommon in clinvarGood
- A;GCarrier of a recessive deafness mutationBad
rs111033299GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs111033335GJB2Important
- CAGTGTTCATGACATTC;GTGTCTGGACarrier of a recessive deafness mutationBad
- GTGTCTGGA;GTGTCTGGAcommon in clinvarGood
rs111033401GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
rs111033451GJB2Important
- G;Gcommon in clinvarGood
- A;GCarrier of a recessive deafness mutationBad
rs143343083GJB2Important
- A;GCarrier of a recessive deafness mutationBad
- G;Gcommon in clinvarGood
rs147541734PTPRQImportant
- C;TCarrier for a recessive mutation for deafnessBad
- T;Tcommon/normalGood
rs150529554GJB2Important
- C;Ccommon in clinvarGood
- C;TCarrier of a recessive deafness mutationBad
rs190166486PTPRQImportant
- A;Acommon/normalGood
- A;GCarrier for a recessive mutation for deafnessBad
rs200023879GJB2Important
- C;GCarrier of a recessive deafness mutationBad
- G;Gcommon in clinvarGood
rs371024165GJB2Important
- A;GCarrier of a recessive deafness mutationBad
- G;Gcommon in clinvarGood
rs397516874GJB2Important
- G;Gcommon in clinvarGood
- A;GCarrier of a recessive deafness mutationBad
rs397516875GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon/normalGood
rs398123814GJB2Important
- -;-common in clinvarGood
- -;CCarrier of a recessive deafness mutationBad
rs529500747GJB2Important
- A;GCarrier of a recessive deafness mutationBad
- G;Gcommon/normalGood
rs532203068GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- T;Tcommon/normalGood
rs587783646GJB2Important
- -;GTCarrier of a recessive deafness mutationBad
- GT;GTcommon in clinvarGood
rs587783647GJB2Important
- -;GATACarrier of a recessive deafness mutationBad
- GATA;GATAcommon in clinvarGood
rs730880338GJB2Important
- -;-common/normalGood
- -;ACarrier of a recessive deafness mutationBad
rs749210663PTPRQImportant
- -;ACarrier for a recessive mutation for deafnessBad
- A;Acommon/normalGood
rs756484720GJB2Important
- -;-Carrier of a recessive deafness mutationBad
- TT;TTcommon in clinvarGood
rs767178508GJB2Important
- A;CCarrier of a recessive deafness mutationBad
- C;Ccommon/normalGood
- C;TCarrier of a recessive deafness mutationBad
rs771748289GJB2Important
- A;GCarrier of a recessive deafness mutationBad
- G;Gcommon in clinvarGood
rs772264564GJB2Important
- A;Acommon in clinvarGood
- A;TCarrier of a recessive deafness mutationBad
rs773528125GJB2Important
- -;-common in clinvarGood
- -;CGTTCarrier of a recessive deafness mutationBad
- D;Dcommon genotypeGood
rs781534323GJB2Important
- C;GCarrier of a recessive deafness mutationBad
- G;Gcommon in clinvarGood
rs786204491GJB2Important
- -;-common in clinvarGood
- -;TCarrier of a recessive deafness mutationBad
rs786204597GJB2Important
- C;TCarrier of a recessive deafness mutationBad
- C;Ccommon in clinvarGood
- A;CCarrier of a recessive deafness mutationBad
rs786204690GJB2Important
- G;TCarrier of a recessive deafness mutationBad
- G;Gcommon in clinvarGood
rs786204734GJB2Important
- C;Ccommon in clinvarGood
- A;CCarrier of a recessive deafness mutationBad
rs797045596GJB2Important
- -;GAAGTTCATCAAGGGGCarrier of a recessive deafness mutationBad
- AGTTCATCAAGGGGGA;AGTTCATCAAGGGGGAcommon in clinvarGood

Genes

Source and license

Adapted from Deafness on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.

Deafness

Linked SNPs

Genes

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Source and license