rs74315438

A SNP in the LOC105369301 gene on chromosome 21. Its most notable genotype is T;T: Deafness; early-onset (prelingual)

Gene
LOC105369301
Location
Chr 2136,461,395 (GRCh38)
Highest magnitude
6.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadDeafness; early-onset (prelingual)Very important · 6.0
  2. C;TBadCarrier of a deafness mutationImportant · 3.0
  3. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs74315438 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LOC105369301 SNPs

All LOC105369301 SNPs

Notes

From SNPedia

Notes

rs74315438, also known as c.301G>A, p.Gly101Arg and G101R, represents a variant in the CLDN14 gene on chromosome 21. Inherited in a recessive manner, the minor allele of this SNP is considered pathogenic for a form of deafness; see OMIM and ClinVar sidebars for details.

T;T

see rs74315438

C;T

Unaffected in absence of a second mutation; see rs74315438.

Source and license

Adapted from rs74315438 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.