rs219780

A SNP in the LOC105369301 gene on chromosome 21. Its most notable genotype is C;C: common in complete genomics

Gene
LOC105369301
Location
Chr 2136,461,009 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
15%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in complete genomicsTypical · 0.084% of people

SNPedia records rs219780 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 84%
  • European ancestry (Utah)C;C 70%
  • Han Chinese (Beijing)C;C 100%
  • Japanese (Tokyo)C;C 100%
  • Yoruba (Nigeria)C;C 68%

Conditions, medicines and genes

Other LOC105369301 SNPs

All LOC105369301 SNPs

Notes

From SNPedia

Notes

nature Carriers of two C alleles of this SNP in CLDN14 gene have 1.6 times higher risk of kidney stones. The rs219780(C;C) genotype is also associated with decreased bone mineral density. Note that the risk genotype is the most common in all populations.

Source and license

Adapted from rs219780 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.