rs267606617

A SNP on chromosome MT. Its most notable genotype is G;G: High risk of developing hearing loss after taking aminoglycoside antibiotics

Gene
None listed
Location
Chr MT1,555 (GRCh38)
Highest magnitude
5.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in clinvarTypical · 0.0
  2. G;GMost notableBadHigh risk of developing hearing loss after taking aminoglycoside antibioticsVery important · 5.0

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

m.1555A>G; also commonly known as A1555G First reported in 1993 and subsequently replicated in numerous studies (but not all), individuals who's mitochondria carry a G at position 1555, i.e. rs267606617(G) mitochondria, are at quite high risk of developing permanent hearing loss (deafness) when taking after receiving aminoglycoside antibiotics such as gentamicin, amikacin, tobramycin, neomycin, and streptomycin. The incidence of inner ear toxicity (ototoxicity) varies from 7 to 90% depending of the types of antibiotics used, susceptibility of the patient to such antibiotics, and the duration of antibiotics administration.Wikipedia

G;G

see text and links via main rs-page

Source and license

Adapted from rs267606617 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.