rs28937591

A SNP in the OTOF gene on chromosome 2. Its most notable genotype is C;C: deafness expected

Gene
OTOF
Location
Chr 226,461,756 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. C;CMost notableNot rateddeafness expectedImportant · 3.0

SNPedia records rs28937591 on the minus strand: (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other OTOF SNPs

All OTOF SNPs

Notes

From SNPedia

Notes

deafness

C;C

this is the rare genotype, however it's on the minus strand so 23andMe users will see GG in their RAW data. promethease handles it correctly

Source and license

Adapted from rs28937591 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.