rs786200885

A SNP in the CLDN14 gene on chromosome 21. Its most notable genotype is -;-: Deafness; early-onset (prelingual)

Gene
CLDN14
Location
Chr 2136,461,298 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. -;-Most notableBadDeafness; early-onset (prelingual)Very important · 6.0
  2. -;ABadCarrier of a deafness mutationImportant · 3.0
  3. A;AGoodcommon in clinvarTypical · 0.0

SNPedia records rs786200885 on the minus strand: (-;-), (-;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other CLDN14 SNPs

All CLDN14 SNPs

Notes

From SNPedia

Notes

rs786200885, also known as c.398delT and p.Met133Argfs, represents a variant in the CLDN14 gene on chromosome 21. Inherited in a recessive manner, the minor allele of this SNP is considered pathogenic for a form of deafness; see OMIM and ClinVar sidebars for details.

-;-

see rs786200885

-;A

Unaffected in absence of a second mutation; see rs786200885.

Source and license

Adapted from rs786200885 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.