rs11123857

A SNP in the NPAS2 gene on chromosome 2. Its most notable genotype is A;G: 1.44-fold increased risk of bipolar disorder or major depression

Gene
NPAS2
Location
Chr 2100,987,350 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.068% of people
  2. A;GMost notableBad1.44-fold increased risk of bipolar disorder or major depressionWorth knowing · 2.026% of people
  3. G;GBad2.88-fold risk of bipolar disorder or major depressionWorth knowing · 2.05% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 68% A;G 26% G;G 5%
  • European ancestry (Utah)A;A 57% A;G 34% G;G 10%
  • Han Chinese (Beijing)A;A 98% A;G 2% G;G 0%
  • Japanese (Tokyo)A;A 99% A;G <1% G;G 0%
  • Yoruba (Nigeria)A;A 34% A;G 48% G;G 18%
  • African ancestry (Southwest US)A;A 47% A;G 42% G;G 11%
  • Chinese (Denver)A;A 99% A;G <1% G;G 0%
  • Gujarati IndianA;A 74% A;G 24% G;G 2%
  • Luhya (Kenya)A;A 53% A;G 40% G;G 7%
  • Mexican ancestry (Los Angeles)A;A 71% A;G 28% G;G 2%
  • Maasai (Kenya)A;A 52% A;G 42% G;G 7%
  • TuscanA;A 67% A;G 29% G;G 4%

Conditions, medicines and genes

Other NPAS2 SNPs

All NPAS2 SNPs

Notes

From SNPedia

Notes

blog Association of Circadian Genes with Mood Disorders *rs2287161 *rs10462028 *rs11123857 *rs17083008 *rs885861

Source and license

Adapted from rs11123857 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.