rs11218343
A SNP in the SORL1 gene on chromosome 11. Its most notable genotype is T;T.
- Gene
- SORL1
- Location
- Chr 11121,564,878 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 12%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 73%
- European ancestry (Utah)T;T 94%
- Han Chinese (Beijing)T;T 47%
- Japanese (Tokyo)T;T 38%
- Yoruba (Nigeria)T;T 88%
- African ancestry (Southwest US)T;T 83%
- Chinese (Denver)T;T 50%
- Gujarati IndianT;T 81%
- Luhya (Kenya)T;T 77%
- Mexican ancestry (Los Angeles)T;T 79%
- Maasai (Kenya)T;T 76%
- TuscanT;T 90%
Related
Other SORL1 SNPs
- rs1784931C;Creduced risk for Alzheimers?Minor
- rs10892759A;Areduced risk for Alzheimers?Minor
- rs720099T;Tcommon in complete genomicsTypical
- rs726601C;CnormalTypical
- rs1699103T;TnormalTypical
- rs1784919C;Ccommon in complete genomicsTypical
- rs1792113A;AnormalTypical
- rs1792124G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. (PMCID: PMC3896259 NIHMSID: NIHMS540798), see TABLE 2 for reference to rs11218343 T/C alleles.
Source and license
Adapted from rs11218343 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.