rs1127354(A;A)

Causative for ITPase deficiency; also, reduces risk of anemia due to ribivarin anti-hepatitis C virus therapy

Magnitude
3.2Important
Repute
Bad
Frequency
1%Average of 4 populations
On SNPedia
rs1127354(A;A)
Gene
ITPA

Frequency

Share of people with A;A in each HapMap population.

  • Han Chinese (Beijing)4%
  • European ancestry (Utah)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs1127354

  1. A;CBadlower ITPA production; be aware if treated with mercaptopurineWorth knowing · 2.014% of people
  2. C;CGoodcommon in clinvarTypical · 0.085% of people

All about rs1127354

Notes

From SNPedia

Causative for ITPase deficiency; be aware of higher neutropenia risk if treated with mercaptopurine; yet also, reduced risk of anemia when subject to ribivarin-based anti-hepatitis C virus therapy.

Source and license

Adapted from rs1127354(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.