rs1127354(A;C)

Lower ITPA production; be aware if treated with mercaptopurine

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
14%Average of 4 populations
On SNPedia
rs1127354(A;C)
Gene
ITPA

Frequency

Share of people with A;C in each HapMap population.

  • Japanese (Tokyo)20%
  • European ancestry (Utah)17%
  • Han Chinese (Beijing)13%
  • Yoruba (Nigeria)7%

Other genotypes of rs1127354

  1. A;AMost notableBadCausative for ITPase deficiency; also, reduces risk of anemia due to ribivarin anti-hepatitis C virus therapyImportant · 3.21% of people
  2. C;CGoodcommon in clinvarTypical · 0.085% of people

All about rs1127354

Notes

From SNPedia

see discussion at rs1127354

Source and license

Adapted from rs1127354(A;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.