rs1136201

A SNP in the ERBB2 gene on chromosome 17. Its most notable genotype is A;A: common in clinvar

Gene
ERBB2
Location
Chr 1739,723,335 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in clinvarTypical · 0.077% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 77%
  • European ancestry (Utah)A;A 53%
  • Han Chinese (Beijing)A;A 62%
  • Japanese (Tokyo)A;A 76%
  • Yoruba (Nigeria)A;A 100%
  • African ancestry (Southwest US)A;A 89%
  • Chinese (Denver)A;A 72%
  • Gujarati IndianA;A 75%
  • Mexican ancestry (Los Angeles)A;A 72%
  • Maasai (Kenya)A;A 97%
  • TuscanA;A 77%

Conditions, medicines and genes

Other ERBB2 SNPs

All ERBB2 SNPs

Notes

From SNPedia

Notes

rs1136201 (Ile655Val) is a SNP within ERBB2/HER2 (Human epidermal growth factor receptor 2). (among 56 patients with breast cancer and 45 healthy women) Ile-Val and Val-Val genotypes exhibited highly significant serum HER-2 elevation compared to those homozygous for Ile-Ile among 61 patients with advanced breast cancers and treated by trastuzumab, all cases of cardiotoxicity occurred in the Ile-Val group and there was no cardiac toxicity in the Val-Val and Ile-Val patients, there was no link found between tumor response and survival w/ HER2 genotype

Source and license

Adapted from rs1136201 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.