rs1136287

A SNP in the SERPINF1 gene on chromosome 17. Its most notable genotype is T;T: 3.9x increased risk of wet ARMD in a Taiwanese Chinese population

Gene
SERPINF1
Location
Chr 171,769,982 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.014% of people
  2. C;TBad1.5x increased risk of wet ARMD in a Taiwanese Chinese populationMinor · 1.840% of people
  3. T;TMost notableBad3.9x increased risk of wet ARMD in a Taiwanese Chinese populationWorth knowing · 2.045% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 14% C;T 40% T;T 45%
  • European ancestry (Utah)C;C 15% C;T 36% T;T 49%
  • Han Chinese (Beijing)C;C 20% C;T 50% T;T 31%
  • Japanese (Tokyo)C;C 24% C;T 52% T;T 24%
  • Yoruba (Nigeria)C;C 3% C;T 16% T;T 81%
  • African ancestry (Southwest US)C;C 2% C;T 28% T;T 70%
  • Chinese (Denver)C;C 18% C;T 52% T;T 29%
  • Gujarati IndianC;C 41% C;T 44% T;T 16%
  • Luhya (Kenya)C;C 2% C;T 28% T;T 70%
  • Mexican ancestry (Los Angeles)C;C 17% C;T 52% T;T 31%
  • Maasai (Kenya)C;C 4% C;T 41% T;T 55%
  • TuscanC;C 13% C;T 44% T;T 43%

Conditions, medicines and genes

Other SERPINF1 SNPs

All SERPINF1 SNPs

Notes

From SNPedia

Notes

rs1136287, also known as Met72Thr, is a SNP in the PEDF gene. Analysis of 86 Taiwanese Chinese patients with wet age related macular degeneration (ARMD) found the (T) allele to be more frequent in patients than in controls (50% vs 31%; p =.0005). The rs1136287(T;T) genotype was also more prevalent in patients than in controls (odds ratio 3.9, p = .0015).

T;T

age related macular degeneration

Source and license

Adapted from rs1136287 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.