Age related macular degeneration

32 SNPs linked to Age related macular degeneration across 13 genes, 16 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 32
Notable: 16Magnitude 2 or higher
Well documented: 21
Genes: 13

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs10490924LOC105378525Important
- G;GnormalGood
- G;T2.7x risk for age related macular degenerationBad
- T;T8.2x risk for age related macular degenerationBad
rs11200638HTRA1Important
- A;A~10x increased risk of wet age related macular degenerationBad
- A;G~2x increased risk of age related macular degenerationBad
- G;GnormalGood
rs1061170CFHImportant
- C;C5.9x risk for AMD; higher mortality among nonagenariansBad
- C;T2.5x risk for AMD; higher mortality among nonagenariansBad
- T;Tlower risk for AMD, generally longer live than (C) allele carriersGood
rs4151667CFBImportant
- A;Aage related macular degenerationBad
- A;Tage related macular degenerationBad
- T;Tcommon in clinvarGood
rs1061147CFHWorth knowing
- A;A2.76x increased risk for Age Related Macular Degeneration.Bad
- A;CNormal 0.97x risk for Age Related Macular Degeneration.Good
- C;CReduced 0.34x risk of Age Related Macular Degeneration.Good
rs2511989SERPING1Worth knowing
- T;T0.44x decreased age-related macular degeneration riskGood
- C;T0.63x decreased age-related macular degeneration riskGood
- C;CnormalNot rated
rs3775291TLR3Worth knowing
- T;T0.44x decreased risk for dry age related macular degenerationGood
- C;T0.71x decreased risk for dry age related macular degenerationGood
- C;Ccommon but higher risk of age related macular degenerationBad
rs1329428CFHWorth knowing
- T;TnormalGood
- C;T?Not rated
- C;C2x increased risk for macular degenerationBad
rs4146894PLEKHA1Worth knowing
- T;T9.1x risk for AMD, but replication is lackingNot rated
- C;T2.6x risk for AMDNot rated
- C;CaverageNot rated
rs9332739C2-AS1Worth knowing
- C;C0.47x decreased risk for AMDGood
- C;G0.47x decreased risk for AMDGood
- G;GnormalGood
rs572515CFHWorth knowing
- G;GNo summary available.Not rated
- A;ANo summary available.Not rated
rs800292CFHWorth knowing
- G;G5% higher risk of Age related macular degenerationBad
- A;G1% decreased risk of macular degenerationGood
- A;A5% decreased risk of macular degenerationGood
rs1136287SERPINF1Worth knowing
- C;CnormalGood
- C;T1.5x increased risk of wet ARMD in a Taiwanese Chinese populationBad
- T;T3.9x increased risk of wet ARMD in a Taiwanese Chinese populationBad
rs3025039VEGFAWorth knowing
- C;CnormalNot rated
- C;T2.6x increased risk for ARMD in a Taiwanese populationBad
- T;T2.6x increased risk for ARMD in a Taiwanese populationBad
rs3732378CX3CR1Worth knowing
- A;Amore rapid progression to full-blown AIDS and probably increased susceptibility to HIV infectionBad
- A;Gpossible reduced risk of acute coronary eventsGood
- G;Gcommon on affy axiom dataGood
rs3793784ERCC6Worth knowing
- G;GnormalNot rated
- C;G1.5x risk for ARMDBad
- C;C1.6x risk for ARMDBad
rs529825CFHTypical
- G;GNo summary available.Not rated
rs641153CFBTypical
- G;Gcommon in clinvarGood
rs3753396CFHTypical
- A;Acommon in clinvarGood
rs3766404CFHTypical
- T;TNo summary available.Not rated
rs28357980ND2Typical
- A;AnormalGood
- A;G2x increased risk for age-related macular degenerationNot rated
- G;GNo summary available.Not rated

Genes

Genosets

Gs134Age related macular degenerationWorth knowing

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 11 SNPs

Source and license

Adapted from Age related macular degeneration on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.