rs28357980

A SNP in the ND2 gene on chromosome MT. Its most notable genotype is A;A: normal

Gene
ND2
Location
Chr MT4,917 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.097% of people
  2. A;GNot rated2x increased risk for age-related macular degenerationTypical · 0.0<1% of people
  3. G;GNot ratedNo summary available.Typical · 0.02% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 97% A;G <1% G;G 2%
  • European ancestry (Utah)A;A 89% A;G 2% G;G 9%
  • Han Chinese (Beijing)A;A 100% A;G 0% G;G 0%
  • Japanese (Tokyo)A;A 100% A;G 0% G;G 0%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%

Conditions, medicines and genes

Other ND2 SNPs

All ND2 SNPs

Notes

From SNPedia

Notes

Also known as mitochondrial SNP 4917G. PLoS This SNP predicts the presence of age related macular degeneration (odds ratio = 2.16, CI: 1.20-3.91, p = 0.01). ThinkGene coverage

A;A

common for Caucasians on the 23andme platform

G;G

also known as is a mitochondrial snp 4917G PLoS this snp predicts the presence of age related macular degeneration (OR = 2.16, 95%CI 1.20–3.91, p = 0.01). This genotype is likely to have many other effects

Source and license

Adapted from rs28357980 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.