rs4146894(T;T)

9.1x risk for AMD, but replication is lacking

Magnitude
2.1Worth knowing
Repute
Not rated
Frequency
23%Average of 11 populations
On SNPedia
rs4146894(A;A)Minus strand
Gene
PLEKHA1

Frequency

Share of people with T;T in each HapMap population.

  • Han Chinese (Beijing)44%
  • Chinese (Denver)36%
  • Japanese (Tokyo)33%
  • Mexican ancestry (Los Angeles)32%
  • Gujarati Indian26%
  • European ancestry (Utah)18%
  • Tuscan17%
  • Luhya (Kenya)16%
  • Yoruba (Nigeria)11%
  • African ancestry (Southwest US)11%
  • Maasai (Kenya)10%

Other genotypes of rs4146894

  1. C;TNot rated2.6x risk for AMDTypical · 0.048% of people
  2. C;CNot ratedaverageTypical · 0.028% of people

All about rs4146894

Notes

From SNPedia

A study in 2007 identified this and two other variants (rs10490924 and rs11200638) as indicating a 9x risk of age related macular degeneration. The other two snps are now well replicated, but replications of the snp you have are still lacking.

Source and license

Adapted from rs4146894(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.