rs1061170

A SNP in the CFH gene on chromosome 1. Its most notable genotype is C;C: 5.9x risk for AMD; higher mortality among nonagenarians

Gene
CFH
Location
Chr 1196,690,107 (GRCh38)
Highest magnitude
3.2Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad5.9x risk for AMD; higher mortality among nonagenariansImportant · 3.2<1% of people
  2. C;TBad2.5x risk for AMD; higher mortality among nonagenariansWorth knowing · 2.533% of people
  3. T;TGoodlower risk for AMD, generally longer live than (C) allele carriersMinor · 1.666% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C <1% C;T 33% T;T 66%
  • European ancestry (Utah)C;C 0% C;T 58% T;T 42%
  • Han Chinese (Beijing)C;C 0% C;T 13% T;T 87%
  • Japanese (Tokyo)C;C 0% C;T 11% T;T 89%
  • Yoruba (Nigeria)C;C 2% C;T 50% T;T 48%

Conditions, medicines and genes

Other CFH SNPs

All CFH SNPs

Notes

From SNPedia

Show notes, about 330 words

rs1061170 is a SNP in the complement factor H CFH gene; it is also known as Tyr402His or p.Y402H. The rs1061170(T) allele encodes the more common Tyr (Y), while the generally rarer rs1061170(C) encodes the His (H). This SNP has been associated primarily with age related macular degeneration, and to a lesser extent, with longevity. This research paper shows that CFH Y402H is the relevant mutation. A haplotype of rs1061170 rs3753394 rs800292 rs1329428 (TGTC) was found to confer a significantly increased likelihood of exudative AMD. rs1061170 (aka Y402H 1277 T>C) was not associated with exudative AMD. CFH variations appear to contribute to ARMD in Caucasians, but not in Japanese CFH variant rs1061170 Y402H is strongly associated with both dry and wet AMD rs1061170(C) alleles are significantly associated with increased susceptibility to early AMD in Taiwan Chinese populations. Some SNPs in other genes (like C7 and MBL2) may protect individuals with one or two of the rs1061170(C) risk alleles. An analysis of the joint effects of rs1061170, rs11200638 and rs10490924 on AMD In a 4 year study of longevity of 491 nonagenarians in the Finnish Vitality 90+ study, risk factor-adjusted mortality was significantly higher among the rs1061170(C) carriers compared to non-carriers (odds ratio 1.78, CI 1.19-2.67, p = 0.005), and the survival curves of these carriers and non-carriers deviated significantly (p = 0.016). In other words, in this study, rs1061170(T;T) individuals generally lived longer than (C) allele carriers. age related macular degeneration

C;C

To minimize your risk of age related macular degeneration, consider a diet rich in vitamins C and E, lutein, zeaxanthin and the minerals zinc and copper, such as kale, spinach and broccoli. source

C;T

To minimize your risk of age related macular degeneration, consider a diet rich in vitamins C and E, lutein, zeaxanthin and the minerals zinc and copper, such as kale, spinach and broccoli. source

Source and license

Adapted from rs1061170 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.