rs380390

A SNP in the CFH gene on chromosome 1. Its most notable genotype is G;G: increased risk for ARMD

Gene
CFH
Location
Chr 1196,731,921 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
26%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadincreased risk for ARMDWorth knowing · 2.17% of people
  2. C;GNot ratedNo summary available.Typical · 0.028% of people
  3. C;CNot ratedNo summary available.Typical · 0.066% of people

SNPedia records rs380390 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 7% C;G 28% C;C 66%
  • European ancestry (Utah)G;G 22% C;G 46% C;C 32%
  • Han Chinese (Beijing)G;G 0% C;G 16% C;C 84%
  • Japanese (Tokyo)G;G 2% C;G 9% C;C 89%
  • Yoruba (Nigeria)G;G 3% C;G 40% C;C 57%

Other CFH SNPs

All CFH SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

linked to blindness in old age rs3753394, rs800292, rs1061147, rs1061170, rs380390, and rs1329428 CFH variations appear to contribute to ARMD in Caucasians, but not in Japanese

Source and license

Adapted from rs380390 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.