rs4151667
A SNP in the CFB gene on chromosome 6. Its most notable genotype is A;A: age related macular degeneration
- Gene
- CFB
- Location
- Chr 631,946,247 (GRCh38)
- Highest magnitude
- 3.1Important
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 3%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadage related macular degeneration
- A;TBadage related macular degeneration
- T;TGoodcommon in clinvar
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A <1% A;T 7% T;T 93%
- European ancestry (Utah)A;A 2% A;T 9% T;T 89%
- Han Chinese (Beijing)A;A 0% A;T 9% T;T 91%
- Japanese (Tokyo)A;A 0% A;T 5% T;T 96%
- Yoruba (Nigeria)A;A 0% A;T 5% T;T 95%
Related
Conditions, medicines and genes
Other CFB SNPs
- rs12614C;Ccommon in clinvarTypical
- rs522162T;Tcommon in complete genomicsTypical
- rs541862T;Tcommon on affy axiom dataTypical
- rs641153G;Gcommon in clinvarTypical
- rs1048709A;Acommon in clinvarTypical
- rs1270942A;Acommon on affy axiom dataTypical
- rs3880457T;Tcommon in complete genomicsTypical
- rs4151659A;Acommon in complete genomicsTypical
Notes
From SNPedia
Notes
age related macular degeneration
Source and license
Adapted from rs4151667 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.