rs12614
A SNP in the CFB gene on chromosome 6. Its most notable genotype is C;C: common in clinvar
- Gene
- CFB
- Location
- Chr 631,946,402 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 17%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 66%
- European ancestry (Utah)C;C 81%
- Han Chinese (Beijing)C;C 85%
- Japanese (Tokyo)C;C 82%
- Yoruba (Nigeria)C;C 39%
- African ancestry (Southwest US)C;C 46%
- Chinese (Denver)C;C 91%
- Gujarati IndianC;C 72%
- Luhya (Kenya)C;C 42%
- Mexican ancestry (Los Angeles)C;C 81%
- Maasai (Kenya)C;C 32%
- TuscanC;C 72%
Related
Other CFB SNPs
- rs4151667A;Aage related macular degenerationImportant
- rs522162T;Tcommon in complete genomicsTypical
- rs541862T;Tcommon on affy axiom dataTypical
- rs641153G;Gcommon in clinvarTypical
- rs1048709A;Acommon in clinvarTypical
- rs1270942A;Acommon on affy axiom dataTypical
- rs3880457T;Tcommon in complete genomicsTypical
- rs4151659A;Acommon in complete genomicsTypical
Source and license
Adapted from rs12614 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.