rs3766404
A SNP in the CFH gene on chromosome 1. Its most notable genotype is T;T.
- Gene
- CFH
- Location
- Chr 1196,682,702 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 62%
- European ancestry (Utah)T;T 74%
- Han Chinese (Beijing)T;T 83%
- Japanese (Tokyo)T;T 84%
- Yoruba (Nigeria)T;T 18%
- African ancestry (Southwest US)T;T 35%
- Chinese (Denver)T;T 82%
- Gujarati IndianT;T 50%
- Luhya (Kenya)T;T 46%
- Mexican ancestry (Los Angeles)T;T 84%
- Maasai (Kenya)T;T 55%
- TuscanT;T 69%
Related
Conditions, medicines and genes
Other CFH SNPs
- rs1061170C;C5.9x risk for AMD; higher mortality among nonagenariansImportant
- rs1061147A;A2.76x increased risk for Age Related Macular Degeneration.Worth knowing
- rs380390G;Gincreased risk for ARMDWorth knowing
- rs1329428C;C2x increased risk for macular degenerationWorth knowing
- rs572515A;ANo summary available.Worth knowing
- rs800292G;G5% higher risk of Age related macular degenerationWorth knowing
- rs460184T;Tcommon in clinvarTypical
- rs460897G;GNo summary available.Typical
Notes
From SNPedia
Notes
age related macular degeneration Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration. Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.
Source and license
Adapted from rs3766404 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.