rs2511989
A SNP in the SERPING1 gene on chromosome 11. Its most notable genotype is T;T: 0.44x decreased age-related macular degeneration risk
- Gene
- SERPING1
- Location
- Chr 1157,610,852 (GRCh38)
- Highest magnitude
- 2.2Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 32%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableGood0.44x decreased age-related macular degeneration risk
- C;TGood0.63x decreased age-related macular degeneration risk
- C;CNot ratednormal
SNPedia records rs2511989 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 13% C;T 38% C;C 48%
- European ancestry (Utah)T;T 22% C;T 41% C;C 37%
- Han Chinese (Beijing)T;T <1% C;T 19% C;C 80%
- Japanese (Tokyo)T;T 4% C;T 27% C;C 69%
- Yoruba (Nigeria)T;T 12% C;T 51% C;C 37%
- African ancestry (Southwest US)T;T 18% C;T 44% C;C 39%
- Chinese (Denver)T;T 2% C;T 17% C;C 81%
- Gujarati IndianT;T 22% C;T 53% C;C 26%
- Luhya (Kenya)T;T 23% C;T 47% C;C 30%
- Mexican ancestry (Los Angeles)T;T 10% C;T 35% C;C 55%
- Maasai (Kenya)T;T 17% C;T 43% C;C 40%
- TuscanT;T 16% C;T 46% C;C 38%
Related
Conditions, medicines and genes
Other SERPING1 SNPs
- rs28940870A;CHereditary angioedema, type IIVery important
- rs112565881G;THereditary angioedema, type IVery important
- rs121907947A;GHereditary angioedema, type IIVery important
- rs121907948A;CHereditary angioedema, type IIVery important
- rs121907949A;THereditary angioedema, type IIVery important
- rs121907950C;TPartial deficiency of complement component 4Very important
- rs121907951C;GHereditary angioedema, type IVery important
- rs201363394T;THereditary angioedema, type IVery important
Notes
From SNPedia
Notes
news rs2511989 not associated with AMD rs2511989(A;A) had a protective effect against age related macular degeneration. Comparison of the rs2511989(A;G) genotype and the wild type (G;G) genotype yielded an odds ratio of 0.63 (CI: 0.47 to 0.84) for age-related macular degeneration. Comparison of rs2511989(A;A) homozygotes with (G;G) homozygotes resulted in an odds ratio of 0.44 (CI: 0.31 to 0.64).
Source and license
Adapted from rs2511989 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.