rs28940870
A SNP in the SERPING1 gene on chromosome 11. Its most notable genotype is A;C: Hereditary angioedema, type II
- Gene
- SERPING1
- Location
- Chr 1157,614,474 (GRCh38)
- Highest magnitude
- 4.1Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;ABadtype II hereditary angioedema
- A;CMost notableBadHereditary angioedema, type II
- C;CGoodnormal
- C;TBadHereditary angioedema
- T;TBadtype II hereditary angioedema
On SNPedia: (A;A), (A;C), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other SERPING1 SNPs
- rs112565881G;THereditary angioedema, type IVery important
- rs121907947A;GHereditary angioedema, type IIVery important
- rs121907948A;CHereditary angioedema, type IIVery important
- rs121907949A;THereditary angioedema, type IIVery important
- rs121907950C;TPartial deficiency of complement component 4Very important
- rs121907951C;GHereditary angioedema, type IVery important
- rs201363394T;THereditary angioedema, type IVery important
- rs281875170A;GHereditary angioedemaVery important
Notes
From SNPedia
Notes
rs28940870 represents two dominant (though rare) mutations in the SERPING1 gene, resulting in type II hereditary angioedema. rs28940870(A) is also known as c.1396C>A, p.Arg466Ser, R466S, Arg444Ser and R444S; rs28940870(T) is also known as c.1396C>T, p.Arg466Cys, R466C, Arg444Cys and R444C. 23andMe name for c.1396C>A: i6018367
A;C
see links via main rs-page and to angioedema
C;T
see links via main rs-page and to angioedema
Source and license
Adapted from rs28940870 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.