rs121907948
A SNP in the SERPING1 gene on chromosome 11. Its most notable genotype is A;C: Hereditary angioedema, type II
- Gene
- SERPING1
- Location
- Chr 1157,614,475 (GRCh38)
- Highest magnitude
- 4.1Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;CMost notableBadHereditary angioedema, type II
- A;GBadHereditary angioedema, type II
- G;GGoodcommon in clinvar
On SNPedia: (A;C), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other SERPING1 SNPs
- rs28940870A;CHereditary angioedema, type IIVery important
- rs112565881G;THereditary angioedema, type IVery important
- rs121907947A;GHereditary angioedema, type IIVery important
- rs121907949A;THereditary angioedema, type IIVery important
- rs121907950C;TPartial deficiency of complement component 4Very important
- rs121907951C;GHereditary angioedema, type IVery important
- rs201363394T;THereditary angioedema, type IVery important
- rs281875170A;GHereditary angioedemaVery important
Notes
From SNPedia
Notes
NM_000062.2(SERPING1):c.1397G>C (p.Arg466Pro) and NM_000062.2(SERPING1):c.1397G>A (p.Arg466His) 23andMe name for c.1397G>A: i5000468
A;C
see links via main rs-page and to angioedema
A;G
see links via main rs-page and to angioedema
Source and license
Adapted from rs121907948 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.