rs3775291

rs3775291 is a SNP in the TLR3 gene associated with an amino acid change in the corresponding protein. In the orientation as shown in dbSNP, the more common rs3775291(G) allele encodes a leucine while the rarer rs3775291(A) allele encodes a phenylalanine. rs3775291 has been associated with one form of age related macular degeneration (ARMD), specifically, the form known as "dry" ARMD, also known as geographic atrophy. A study of 3 case-control groups of Americans of European descent, comprising about 900 ARMD patients in total, indicated that having one rs3775291(A) allele reduces the odds of having dry ARMD about 30%, and being a rs3775291(A;A) homozygote cuts your odds by more than half. Specifically, the odds ratio of having dry ARMD with one minor allele is 0.712 (CI: 0.50-1.0), and for two minor alleles, 0.437 ( CI: 0.227-0.839). This was highly significant for the pooled populations (p = 1.24x10e–7) and also in each population independently(p = 0.002-0.005). Results of three independent samples did not confirm previously reported association of rs3775291 with AMD, individually or combined. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Toll-like receptor polymorphisms and age-related macular degeneration. Vaccine immunogenetics: bedside to bench to population. Personalized vaccines: the emerging field of vaccinomics. Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis. Molecular pathology of age-related macular degeneration. Multilocus analysis of age-related macular degeneration. Toll-like receptor signaling pathway variants and prostate cancer mortality. Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects. A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection. Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population. Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.

T;T

Some association has been reported between polymorphisms in TLR genes and age related macular degeneration(ARMD). However, these variants are not likely to have a major impact of the overall risk of developing macular degeneration.