rs3753396
A SNP in the CFH gene on chromosome 1. Its most notable genotype is A;A: common in clinvar
- Gene
- CFH
- Location
- Chr 1196,726,612 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 64%
- European ancestry (Utah)A;A 74%
- Han Chinese (Beijing)A;A 24%
- Japanese (Tokyo)A;A 31%
- Yoruba (Nigeria)A;A 95%
- African ancestry (Southwest US)A;A 84%
- Chinese (Denver)A;A 27%
- Gujarati IndianA;A 82%
- Luhya (Kenya)A;A 92%
- Mexican ancestry (Los Angeles)A;A 55%
- Maasai (Kenya)A;A 77%
- TuscanA;A 68%
Related
Conditions, medicines and genes
Other CFH SNPs
- rs1061170C;C5.9x risk for AMD; higher mortality among nonagenariansImportant
- rs1061147A;A2.76x increased risk for Age Related Macular Degeneration.Worth knowing
- rs380390G;Gincreased risk for ARMDWorth knowing
- rs1329428C;C2x increased risk for macular degenerationWorth knowing
- rs572515A;ANo summary available.Worth knowing
- rs800292G;G5% higher risk of Age related macular degenerationWorth knowing
- rs460184T;Tcommon in clinvarTypical
- rs460897G;GNo summary available.Typical
Notes
From SNPedia
Show notes, about 120 words
age related macular degeneration A forest-based approach to identifying gene and gene gene interactions. Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. Plasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. A particle swarm based hybrid system for imbalanced medical data sampling. Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
Source and license
Adapted from rs3753396 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.