rs11405
A SNP in the PSEN2 gene on chromosome 1. Its most notable genotype is T;T: common in clinvar
- Gene
- PSEN2
- Location
- Chr 1226,881,976 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 8%
- European ancestry (Utah)T;T <1%
- Han Chinese (Beijing)T;T 29%
- Japanese (Tokyo)T;T 9%
- Yoruba (Nigeria)T;T 2%
- African ancestry (Southwest US)T;T 5%
- Chinese (Denver)T;T 18%
- Gujarati IndianT;T 7%
- Luhya (Kenya)T;T <1%
- Mexican ancestry (Los Angeles)T;T 7%
- Maasai (Kenya)T;T 2%
- TuscanT;T 5%
Related
Other PSEN2 SNPs
- rs28936379A;Gearly-onset Alzheimers diseaseVery important
- rs28936380C;Gearly-onset Alzheimer's diseaseVery important
- rs63749851A;CEarly-onset Alzheimer's diseaseVery important
- rs63750215A;Tearly-onset Alzheimer's diseaseVery important
- rs61761208A;TEarly-onset Alzheimer's mutation (reported)Very important
- rs63749884A;Gearly-onset Alzheimer's disease; penetrance not 100%Very important
- rs63750666C;Tearly-onset Alzheimer's disease; penetrance unclearVery important
- rs200754713A;GFrontotemporal dementia (reported)Very important
Notes
From SNPedia
Notes
A SNP in the presenilin gene PSEN2.
Source and license
Adapted from rs11405 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.