rs1143627

A SNP in the IL1B gene on chromosome 2. Its most notable genotype is G;G: common in clinvar

Gene
IL1B
Location
Chr 2112,836,810 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
48%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.031% of people

SNPedia records rs1143627 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 31%
  • European ancestry (Utah)G;G 13%
  • Han Chinese (Beijing)G;G 24%
  • Japanese (Tokyo)G;G 24%
  • Yoruba (Nigeria)G;G 47%
  • African ancestry (Southwest US)G;G 44%
  • Chinese (Denver)G;G 28%
  • Gujarati IndianG;G 34%
  • Luhya (Kenya)G;G 52%
  • Mexican ancestry (Los Angeles)G;G 28%
  • Maasai (Kenya)G;G 40%
  • TuscanG;G 13%

Notes

From SNPedia

Show notes, about 630 words

associated with ankylosing spondylitis risk of Helicobacter pylori infection. Children carrying IL1A-889T had a lower risk of H. pylori positivity, compared to those carrying -889C, with each T allele associated with 43% risk reduction (OR = 0.57, 95% CI = 0.33-0.99, p-trend = .05) upregulation of pro-inflammatory cytokines may protect against persistent H. pylori colonization. Association study of functional genetic variants of innate immunity related genes in celiac disease. Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk. Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. A genome-wide association study identifies protein quantitative trait loci (pQTLs). A broad analysis of IL1 polymorphism and rheumatoid arthritis. Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Concurrent genotyping of Helicobacter pylori virulence genes and human cytokine SNP sites using whole genome amplified DNA derived from minute amounts of gastric biopsy specimen DNA. Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders. Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies. A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer. Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine. Pharmacogenetics of antidepressant response. Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review. Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study. Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin.

Source and license

Adapted from rs1143627 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.