rs1143634

A SNP in the IL1B gene on chromosome 2. Its most notable genotype is G;G: normal

Gene
IL1B
Location
Chr 2112,832,813 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodnormalTypical · 0.077% of people
  2. A;GNot ratedcomplex; see detailsTypical · 0.020% of people
  3. A;ANot ratedcomplex; see detailsTypical · 0.02% of people

SNPedia records rs1143634 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 77% A;G 20% A;A 2%
  • European ancestry (Utah)G;G 64% A;G 31% A;A 5%
  • Han Chinese (Beijing)G;G 97% A;G 3% A;A 0%
  • Japanese (Tokyo)G;G 89% A;G 11% A;A 0%
  • Yoruba (Nigeria)G;G 82% A;G 16% A;A 2%
  • African ancestry (Southwest US)G;G 79% A;G 21% A;A 0%
  • Chinese (Denver)G;G 97% A;G 3% A;A 0%
  • Gujarati IndianG;G 70% A;G 22% A;A 8%
  • Luhya (Kenya)G;G 71% A;G 28% A;A <1%
  • Mexican ancestry (Los Angeles)G;G 76% A;G 24% A;A 0%
  • Maasai (Kenya)G;G 67% A;G 28% A;A 5%
  • TuscanG;G 56% A;G 38% A;A 6%

Conditions, medicines and genes

Other IL1B SNPs

All IL1B SNPs

Notes

From SNPedia

Show notes, about 320 words

rs1143634, also known as +3954, is a SNP in the IL-1 beta IL1B gene. A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1143634(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers. rs1143634 increases susceptibility to Alopecia Areata 2.67 times for heterozygotes (CT) and 1.13 times for homozygotes (TT) rs1143634 increases susceptibility to Alzheimer's disease 2.33 times for homozygotes (TT) rs1143634 increases susceptibility to Cervical lesions, low-grade squamous intraepithelial lesions 4.29 times for heterozygotes (CT) and 3.57 times for homozygotes (TT) rs1143634 increases susceptibility to Duodenal ulcer 1.14 times for carriers of the T allele rs1143634 increases susceptibility to Inflammatory bowel disease 7.32 times for carriers of the T allele rs1143634 increases susceptibility to Joint destruction in Rheumatoid Arthritis 1.70 times for carriers of the T allele rs1143634 increases susceptibility to Myasthenia gravis 1.29 times for heterozygotes (CT) and 4.63 times for homozygotes (TT) rs1143634 increases susceptibility to Nephropathy in Type I Diabetes 2.03 times for heterozygotes (CT) and 5.01 times for homozygotes (TT) rs1143634 increases susceptibility to Peptic ulcer disease 1.06 times for carriers of the T allele rs1143634 increases susceptibility to Periodontitis 2.85 times for heterozygotes (CT) and 4.89 times for homozygotes (TT) rs1143634 increases susceptibility to Periodontitis 3.33 times for carriers of the T allele rs1143634 increases susceptibility to Survival in pancreatic cancer for carriers of the T allele rs1143634 increases susceptibility to Ulcerative colitis 1.89 times for heterozygotes (CT) and 1.59 times for homozygotes (TT)

Source and license

Adapted from rs1143634 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.