rs11672691

A SNP in the PCAT19 gene on chromosome 19. Its most notable genotype is G;G: 1.39x increased risk for PCSM in patients with prostate cancer

Gene
PCAT19
Location
Chr 1941,479,679 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GBad1.18x increased risk for PCSM in patients with prostate cancerWorth knowing · 2.036% of people
  2. G;GMost notableBad1.39x increased risk for PCSM in patients with prostate cancerWorth knowing · 2.530% of people

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;G 36% G;G 30%
  • European ancestry (Utah)A;G 42% G;G 51%
  • Han Chinese (Beijing)A;G 44% G;G 43%
  • Japanese (Tokyo)A;G 48% G;G 27%
  • Yoruba (Nigeria)A;G 18% G;G <1%
  • African ancestry (Southwest US)A;G 27% G;G 7%
  • Chinese (Denver)A;G 49% G;G 39%
  • Gujarati IndianA;G 42% G;G 47%
  • Luhya (Kenya)A;G 11% G;G <1%
  • Mexican ancestry (Los Angeles)A;G 50% G;G 47%
  • Maasai (Kenya)A;G 31% G;G 1%
  • TuscanA;G 34% G;G 62%

Conditions, medicines and genes

Other PCAT19 SNPs

All PCAT19 SNPs

Notes

From SNPedia

Show notes, about 220 words

rs11672691 is a SNP on chromosome 19 located between the ATP5SL and CEACAM21 genes and within LOC100505495, a possible noncoding RNA. A large study of over 10,000 patients with prostate cancer concluded that each rs11672691(G) allele was associated with an increased risk (by 1.18x) of prostate cancer specific mortality (PCSM), i.e. death from the cancer. A meta-analysis of 4 studies totaling ~6000 patients with prostate cancer and follow up in 49,000 samples concluded that rs11672691 was associated with increased susceptibility (odds ratio 1.12, CI:1.03&#8211;1.21, p = 1.4 x 10e-8) but also with aggressive prostate cancer and therefore a poorer prognosis. A study published in Cell in 2018 suggests that the rs11672691(G) variant acts to increase the transcript levels of PCAT19 and CEACAM21, two proteins associated with cell growth and tumor progression.

A;G

For a person already diagnosed with prostate cancer, this relatively common genotype is associated with a more aggressive form of the cancer and an increased risk (by 1.18x) of dying from causes related to the cancer.

G;G

For a person already diagnosed with prostate cancer, this relatively common genotype is associated with a more aggressive form of the cancer and an increased risk (by 1.39x) of dying from causes related to the cancer.

Source and license

Adapted from rs11672691 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.