rs887391

A SNP in the PCAT19 gene on chromosome 19. Its most notable genotype is C;C: Lower prostate cancer risk?

Gene
PCAT19
Location
Chr 1941,479,716 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodLower prostate cancer risk?Minor · 1.516% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 16%
  • European ancestry (Utah)C;C 6%
  • Han Chinese (Beijing)C;C 13%
  • Japanese (Tokyo)C;C 19%
  • Yoruba (Nigeria)C;C 30%
  • African ancestry (Southwest US)C;C 30%
  • Chinese (Denver)C;C 11%
  • Gujarati IndianC;C 12%
  • Luhya (Kenya)C;C 31%
  • Mexican ancestry (Los Angeles)C;C 2%
  • Maasai (Kenya)C;C 19%
  • TuscanC;C 4%

Conditions, medicines and genes

Other PCAT19 SNPs

All PCAT19 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs887391 was the most strongly associated SNP in the 19q13 region, which was a region highly associated with prostate cancer (p=9.4 x 10(-4)) based on two large studies. Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients. Prostate cancer risk associated loci in African Americans.

C;C

However, a highly significant association was found for the SNP rs887391 at 19q13. The frequency of risk allele ‘T’ was significantly higher in cases (0.76) than in controls (0.73), P=9.4 × 10−4. As a third-stage confirmation, we genotyped this SNP in 1,527 PCa patients and 482 control subjects of European descent from Johns Hopkins Hospital (JHH). The risk allele ‘T’ was more common in cases (0.79) than controls (0.78), although the difference was not significant (P=0.43).

References

Source and license

Adapted from rs887391 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.