rs1169305
A SNP in the HNF1A gene on chromosome 12. Its most notable genotype is A;G: associated with MODY3; maturity onset of diabetes in the young (type 3)
- Gene
- HNF1A
- Location
- Chr 12120,999,579 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in complete genomics
- A;GMost notableBadassociated with MODY3; maturity onset of diabetes in the young (type 3)
- A;AGoodcommon in clinvar
SNPedia records rs1169305 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 96% A;G 4% A;A 0%
- European ancestry (Utah)G;G 100% A;G 0% A;A 0%
- Han Chinese (Beijing)G;G 100% A;G 0% A;A 0%
- Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
- Yoruba (Nigeria)G;G 83% A;G 18% A;A 0%
Related
Other HNF1A SNPs
- rs137853236C;TMaturity onset of diabetes of the young (type 3)Important
- rs137853237A;GMaturity onset of diabetes of the young (type 3)Important
- rs137853239C;GMature onset diabetes of the young (type 3)Important
- rs137853243C;TMaturity onset of diabetes of the young (type 3)Important
- rs137853244C;TMaturity onset of diabetes of the young (type 3)Important
- rs137853245A;CMaturity onset of diabetes of the young (type 3)Important
- rs137853246C;GMaturity onset of diabetes of the young (type 3)Important
- rs150513055C;TMature onset diabetes of the young (type 3)Important
Notes
From SNPedia
Notes
now considered benign in ClinVar
Source and license
Adapted from rs1169305 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.