rs11718863

A SNP in the DVWA gene on chromosome 3. Its most notable genotype is A;A: normal

Gene
DVWA
Location
Chr 315,175,196 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.056% of people
  2. A;TBad1.43x increased osteoarthritis riskTypical · 0.033% of people
  3. T;TBad1.43x increased osteoarthritis riskTypical · 0.011% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 56% A;T 33% T;T 11%
  • European ancestry (Utah)A;A 72% A;T 28% T;T 0%
  • Han Chinese (Beijing)A;A 33% A;T 38% T;T 29%
  • Japanese (Tokyo)A;A 25% A;T 61% T;T 14%
  • Yoruba (Nigeria)A;A 93% A;T 7% T;T 0%

Conditions, medicines and genes

Other DVWA SNPs

All DVWA SNPs

Notes

From SNPedia

Notes

rs11718863 is one of several SNPs in the DVWA gene found to be associated with osteoarthritis based on a study of several Japanese patient populations. The allelic odds ratio is 1.43 (CI: 1.26-1.63, p = 5.2 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation). Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.

Source and license

Adapted from rs11718863 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.