rs7639618

A SNP in the DVWA gene on chromosome 3. Its most notable genotype is C;T: 1.45x increased osteoarthritis risk

Gene
DVWA
Location
Chr 315,174,922 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.054% of people
  2. C;TMost notableBad1.45x increased osteoarthritis riskWorth knowing · 2.038% of people
  3. T;TBad1.45x increased osteoarthritis riskWorth knowing · 2.08% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 54% C;T 38% T;T 8%
  • European ancestry (Utah)C;C 68% C;T 28% T;T 4%
  • Han Chinese (Beijing)C;C 31% C;T 49% T;T 20%
  • Japanese (Tokyo)C;C 33% C;T 53% T;T 14%
  • Yoruba (Nigeria)C;C 64% C;T 34% T;T 2%
  • African ancestry (Southwest US)C;C 58% C;T 40% T;T 2%
  • Chinese (Denver)C;C 30% C;T 47% T;T 23%
  • Gujarati IndianC;C 42% C;T 51% T;T 8%
  • Luhya (Kenya)C;C 57% C;T 36% T;T 7%
  • Mexican ancestry (Los Angeles)C;C 55% C;T 40% T;T 5%
  • Maasai (Kenya)C;C 72% C;T 22% T;T 5%
  • TuscanC;C 78% C;T 22% T;T 0%

Conditions, medicines and genes

Other DVWA SNPs

All DVWA SNPs

Notes

From SNPedia

Notes

rs7639618 is one of several SNPs in the DVWA gene found to be associated with osteoarthritis based on a study of several Japanese patient populations. The allelic odds ratio is 1.45 (CI: 1.27-1.65, p = 2.2 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation). Our results suggest that the effect that DVWA amino acid changes have on tubulin binding is unlikely to influence risk of OA in Caucasians. rs7639618 with knee osteoarthritis with an odds ratio (OR) of 1.29, 95% confidence interval (CI) of 1.15 -1.45 and P of 2.70x10(-5), but not for Europeans

Source and license

Adapted from rs7639618 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.