rs11842874

A SNP in the MCF2L gene on chromosome 13. Its most notable genotype is A;A: common but +17% risk Osteoarthritis

Gene
MCF2L
Location
Chr 13113,040,195 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadcommon but +17% risk OsteoarthritisMinor · 1.872% of people
  2. A;GBad+17% increased risk for osteoarthritisMinor · 1.225% of people
  3. G;GGoodreduced risk for osteoarthritisMinor · 1.43% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 72% A;G 25% G;G 3%
  • European ancestry (Utah)A;A 87% A;G 13% G;G 0%
  • Han Chinese (Beijing)A;A 65% A;G 30% G;G 5%
  • Japanese (Tokyo)A;A 65% A;G 31% G;G 4%
  • Yoruba (Nigeria)A;A 52% A;G 42% G;G 6%
  • African ancestry (Southwest US)A;A 75% A;G 23% G;G 2%
  • Chinese (Denver)A;A 73% A;G 26% G;G 2%
  • Gujarati IndianA;A 91% A;G 9% G;G 0%
  • Luhya (Kenya)A;A 54% A;G 39% G;G 7%
  • Mexican ancestry (Los Angeles)A;A 78% A;G 22% G;G 0%
  • Maasai (Kenya)A;A 69% A;G 28% G;G 3%
  • TuscanA;A 86% A;G 14% G;G 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs11842874 is a SNP in the MCF.2 cell line derived transforming sequence-like MCF2L gene on ch 13. Based initially on a GWAS study of 3,000 patients of European ancestry with osteoarthritis and then subsequently replicated for a total of 19,000+ cases, the rs11842874(A) allele (major allele) was associated with increased risk, at an odds ratio of 1.17 (CI: 1.11–1.23, p = 2.1 × 10e?8). The authors note that MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee osteoarthritis patients.

A;A

risk 1.17 [1.11–1.23], p = 2.1 × 10−8

References

Source and license

Adapted from rs11842874 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.