rs119103257
A SNP in the PYGM gene on chromosome 11. Its most notable genotype is A;A: McArdle disease (also known as glycogen storage disease type V)
- Gene
- PYGM
- Location
- Chr 1164,752,071 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- A;CBadCarrier of a McArdle disease mutation
- A;AMost notableBadMcArdle disease (also known as glycogen storage disease type V)
SNPedia records rs119103257 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PYGM SNPs
- rs116987552A;AMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103251T;TMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103252G;GMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103253T;TMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103254G;GMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103255A;AMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103256C;CMcArdle disease (also known as glycogen storage disease type V)Very important
- rs119103258T;TMcArdle disease (also known as glycogen storage disease type V)Very important
Notes
From SNPedia
Notes
PYGM gene, c.1621G>T, p.Glu541Ter or E541X 23andMe name: i5005807
A;C
Unaffected in absence of a second mutation in the PYGM gene
Source and license
Adapted from rs119103257 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.