rs11974297

A SNP in the DDC gene on chromosome 7. Its most notable genotype is G;G: Migraine

Gene
DDC
Location
Chr 750,550,562 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadMigraineMinor · 1.028% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 28%
  • European ancestry (Utah)G;G 18%
  • Han Chinese (Beijing)G;G 29%
  • Japanese (Tokyo)G;G 27%
  • Yoruba (Nigeria)G;G 53%
  • African ancestry (Southwest US)G;G 32%
  • Chinese (Denver)G;G 31%
  • Gujarati IndianG;G 23%
  • Luhya (Kenya)G;G 37%
  • Mexican ancestry (Los Angeles)G;G 9%
  • Maasai (Kenya)G;G 31%
  • TuscanG;G 15%

Other DDC SNPs

All DDC SNPs

Notes

From SNPedia

Notes

a haplotype consisting of rs2329340(A), rs11974297(C), rs2044859(T) and rs11761683(G) associated with increased incidence of migraine with aura among a sample of 528 migraine patients (308 without aura, 220 with aura) and 528 sex-matched migraine-free controls

G;G

A four-marker haplotype in DDC was specific to migraine with Aura (rs2329340A, rs11974297C, rs2044859T, rs11761683G)

Source and license

Adapted from rs11974297 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.