rs11978267

A SNP in the IKZF1 gene on chromosome 7. Its most notable genotype is G;G: possible increased risk for infant acute myeloid leukemia (AML)

Gene
IKZF1
Location
Chr 750,398,606 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormal/commonTypical · 0.064% of people
  2. G;GMost notableBadpossible increased risk for infant acute myeloid leukemia (AML)Worth knowing · 2.05% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 64% G;G 5%
  • European ancestry (Utah)A;A 47% G;G 7%
  • Han Chinese (Beijing)A;A 76% G;G 3%
  • Japanese (Tokyo)A;A 87% G;G <1%
  • Yoruba (Nigeria)A;A 62% G;G 7%
  • African ancestry (Southwest US)A;A 63% G;G 5%
  • Chinese (Denver)A;A 76% G;G 4%
  • Gujarati IndianA;A 41% G;G 16%
  • Luhya (Kenya)A;A 62% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 66% G;G 0%
  • Maasai (Kenya)A;A 76% G;G 3%
  • TuscanA;A 46% G;G 7%

Other IKZF1 SNPs

All IKZF1 SNPs

Notes

From SNPedia

Notes

G;G

Although based on a fairly small study (~170 pediatric patients), homozygosity for this relatively rare IKZF1 gene allele has been reported to increase risk (perhaps 3+ fold) of infant acute myeloid leukemia (AML).

Source and license

Adapted from rs11978267 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.