rs4132601

A SNP in the IKZF1 gene on chromosome 7. Its most notable genotype is G;G: moderately (~2.5x) increased risk for acute lymphoblastic leukemia

Gene
IKZF1
Location
Chr 750,402,906 (GRCh38)
Highest magnitude
2.4Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadmoderately (~2.5x) increased risk for acute lymphoblastic leukemiaWorth knowing · 2.45% of people
  2. G;TBadsomewhat (1.7x) increased risk for acute lymphoblastic leukemiaMinor · 1.734% of people
  3. T;TGoodcommon/normalTypical · 0.060% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 5% G;T 34% T;T 60%
  • European ancestry (Utah)G;G 7% G;T 46% T;T 47%
  • Han Chinese (Beijing)G;G 3% G;T 20% T;T 77%
  • Japanese (Tokyo)G;G <1% G;T 12% T;T 87%
  • Yoruba (Nigeria)G;G 6% G;T 34% T;T 60%
  • African ancestry (Southwest US)G;G 5% G;T 35% T;T 60%
  • Chinese (Denver)G;G 3% G;T 19% T;T 78%
  • Gujarati IndianG;G 16% G;T 40% T;T 45%
  • Luhya (Kenya)G;G 4% G;T 45% T;T 52%
  • Mexican ancestry (Los Angeles)G;G 0% G;T 35% T;T 66%
  • Maasai (Kenya)G;G 8% G;T 43% T;T 49%
  • TuscanG;G 7% G;T 48% T;T 45%

Conditions, medicines and genes

Other IKZF1 SNPs

All IKZF1 SNPs

Notes

From SNPedia

Notes

23andMe blog Acute lymphoblastic leukemia *each rs4132601(G) 1.69x odds of ALL *each rs7089424(G) 1.65x odds of ALL *each rs2239633(G) 1.34x odds of ALL A meta-analysis published in 2014 based on a total of 15 case-control studies with 8333 cases and 36036 controls concluded that rs4132601 was associated with increased ALL risk in Caucasians and Hispanics but not among Asians.

G;G

see discussion at rs4132601

G;T

see discussion at rs4132601

Source and license

Adapted from rs4132601 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.