rs12026
A SNP in the PON2 gene on chromosome 7. Its most notable genotype is G;G: common in clinvar
- Gene
- PON2
- Location
- Chr 795,411,704 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 25%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs12026 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 57%
- European ancestry (Utah)G;G 55%
- Han Chinese (Beijing)G;G 62%
- Japanese (Tokyo)G;G 64%
- Yoruba (Nigeria)G;G 47%
Related
Notes
From SNPedia
Notes
reports that one or two copies of a common variation (glycine replacing alanine) present at amino acid 148 of the PON2 protein, rs12026, exacerbates glycemia in non-insulin dependent diabetes mellitus (NIDDM).
Source and license
Adapted from rs12026 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.