rs7493

A SNP in the PON2 gene on chromosome 7. Its most notable genotype is G;G: common in clinvar

Gene
PON2
Location
Chr 795,405,463 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
26%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.055% of people

SNPedia records rs7493 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 55%
  • European ancestry (Utah)G;G 63%
  • Han Chinese (Beijing)G;G 68%
  • Japanese (Tokyo)G;G 69%
  • Yoruba (Nigeria)G;G 43%
  • African ancestry (Southwest US)G;G 58%
  • Chinese (Denver)G;G 66%
  • Gujarati IndianG;G 38%
  • Luhya (Kenya)G;G 36%
  • Mexican ancestry (Los Angeles)G;G 55%
  • Maasai (Kenya)G;G 56%
  • TuscanG;G 59%

Other PON2 SNPs

All PON2 SNPs

Notes

From SNPedia

Notes

rs7493, also known as Ser311Cys, is a missense SNP in the paraoxonase 2 (PON2) gene. A study has shown that inheriting the Cys version encoded by the corresponding SNP results in impaired (lower) lactonase activity; this may (or may not) lead to problems with innate immunity, atherosclerosis, and other diseases.

Source and license

Adapted from rs7493 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.