rs12075

A SNP in the ACKR1 gene on chromosome 1. Its most notable genotype is A;A: Duffy Fy(a-b+) phenotype likely (unless Duffy null mutation is present)

Gene
ACKR1
Location
Chr 1159,205,564 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodDuffy Fy(a-b+) phenotype likely (unless Duffy null mutation is present)Minor · 1.037% of people
  2. A;GGoodDuffy Fy(a+b+) phenotype likely (unless Duffy null mutation is present)Minor · 1.027% of people
  3. G;GGoodDuffy Fy(a+b-) phenotype likely (unless Duffy null mutation is present)Minor · 1.036% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 37% A;G 27% G;G 36%
  • European ancestry (Utah)A;A 28% A;G 55% G;G 17%
  • Han Chinese (Beijing)A;A <1% A;G 11% G;G 88%
  • Japanese (Tokyo)A;A <1% A;G 20% G;G 79%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%
  • African ancestry (Southwest US)A;A 79% A;G 19% G;G 2%
  • Chinese (Denver)A;A 0% A;G 5% G;G 95%
  • Gujarati IndianA;A 13% A;G 54% G;G 34%
  • Mexican ancestry (Los Angeles)A;A 19% A;G 52% G;G 29%
  • Maasai (Kenya)A;A 97% A;G 3% G;G 0%
  • TuscanA;A 32% A;G 53% G;G 15%

Other ACKR1 SNPs

All ACKR1 SNPs

Notes

From SNPedia

Notes

rs12075, also known as c.125G>A, p.Gly42Asp and G42D, represents a well-studied variant in the ACKR1 gene on chromosome 1. This SNP encodes the major co-dominant alleles of the Duffy blood group antigen system (Fy). The rs12075(G) allele encodes Gly42, which is the Fy(a) antigen. The rs12075(A) allele encodes Asp42, the Fy(b) antigen. For some frequencies of the resulting phenotypes for this variant, see the ACKR1 page.

A;A

see discussion at ACKR1 and at rs12075

A;G

see discussion at ACKR1 and at rs12075

G;G

see discussion at ACKR1 and at rs12075

Source and license

Adapted from rs12075 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.