rs34599082

A SNP in the ACKR1 gene on chromosome 1. Its most notable genotype is T;T: Duffy FY(bwk) blood group, and possible malarial resistance

Gene
ACKR1
Location
Chr 1159,205,704 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodDuffy FY(bwk) blood group, and possible malarial resistanceWorth knowing · 2.0
  2. C;TGoodcarrier of a Duffy weak allele, and possible malarial resistanceWorth knowing · 2.0
  3. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs34599082 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ACKR1 SNPs

All ACKR1 SNPs

Notes

From SNPedia

Notes

rs34599082, also known as c.265C>T, p.Arg89Cys and R89C, represents an uncommon variant in the DARC gene on chromosome 1, which is better known for it's role as part of the Duffy blood group (antigen) on red blood cells. Found in ~1% of the population, the rs34599082(A) allele (as represented in dbSNP/minus orientation) encodes the Duffy blood group FY(bwk) phenotype, which is also known as FY-weak. This allele results in lower amounts of DARC protein, and thus lower antigen expression and chemokine binding ability. This variant may offer some protection against infection by malaria.

T;T

see discussion at rs34599082

C;T

see discussion at rs34599082

Source and license

Adapted from rs34599082 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.