rs121434280

A SNP in the ACADM gene on chromosome 1. Its most notable genotype is C;C: Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Gene
ACADM
Location
Chr 175,732,724 (GRCh38)
Highest magnitude
5.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadMedium-Chain Acyl-CoA Dehydrogenase DeficiencyVery important · 5.0
  2. C;TBadCarrier of Medium-Chain Acyl-CoA Dehydrogenase DeficiencyImportant · 3.0
  3. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other ACADM SNPs

All ACADM SNPs

Notes

From SNPedia

Notes

aka c.199T>C, p.Tyr67His), Y67H (and in older literature, Y42H or Tyr42His) According to a paper cited in OMIM, the Y42H mutation is relatively mild as ACADM mutations go, and may be a temperature-sensitive mutation, which its most deleterious effects only at increased temperatures.

Source and license

Adapted from rs121434280 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.