rs121434410

A SNP in the LOC101927027 gene on chromosome 2. Its most notable genotype is A;A: Dystonia, type 16

Gene
LOC101927027
Location
Chr 2178,436,264 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GBadCarrier of a dystonia type 16 mutationImportant · 3.0
  3. A;AMost notableBadDystonia, type 16Very important · 6.0

SNPedia records rs121434410 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

aka c.665C>T (p.Pro222Leu or P222L) Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal recessive dystonia 16 See also OMIM 603424.0001

A;G

Unaffected in absence of a second mutation in the PRKRA gene.

A;A

see text and links via main rs-page

Source and license

Adapted from rs121434410 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.